mercredi 13 novembre 2013

Brain Tumor Research & Work Done With Mice

By Rob Sutter


A report on Medical News Today spoke about how a new therapy was done with mice involved. I think that this is a tremendous way to go about brain tumor research, especially given the idea that these are subjects that have proven useful in the past. If therapies have shown tremendous results for these creatures, it is very likely that they will be able to parlay into the help that humans have. In this particular matter, such results have a chance of occurring.

The article talked about how those within the John Hopkins University School of Medicine have been able to bring this drug into great effect. For those of you not in the know, 5-azacytidine may be able to prove useful in the realm of brain tumor research. You have to keep in mind that it had a previous effect on pre-leukemia in the past. It has since been utilized in this study, which should be focused on by organizations such as Voices against Brain Cancer.

Gliomas - seen as the most common and rapidly growing tumors in the brain - are going to be helped thanks to this drug. In particular, the drug will be able to target the mutation referred to simply as IDH1. For those of you who are unfamiliar with what exactly this entails, it is an alteration that is seen in 70 to 80 percent of all lower-grade tumors in patient. This mutation will make it impossible for the body to utilize protein for the sake of transitioning glucose into energy.

That way that 5-azacytidine was administered was through mice, which was done during a period of 14 weeks. What was seen by the end of the process was that tumor growth had been reduced tremendously and a relapse had not been seen as well. After drug administration had been halted, tumors did not come back after 7 weeks. Tumors have a tough time regressing with certain treatments but that is what the case was in this regard and it is beneficial, to put it lightly.

It's difficult to predict when tumor regression is going to be seen in different studies but the truth of the matter is that it happened here. I don't think you need me to tell you just how important this is to brain tumor research efforts. Mice were treated well as the progression of their growths had been reduced and I have to believe that humans will be able to benefit from this process as well. It's just a matter of time as studies are undoubtedly going to be shifted.




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